For Patients For Medical Professionals

HELPLINE 1-800-465-4837
Mon-Fri 9am – 5pm EST

Hepatic Encephalopathy Information Center


HE Patient


The American Liver Foundation receives contributions and funding from clinical trial and study sponsors but does not evaluate or endorse any clinical trials or studies, and is not affiliated with any of the sponsors.

Hepatic Encephalopathy (HE), sometimes referred to as portosystemic encephalopathy or PSE, is a condition that causes temporary worsening of brain function in people with advanced liver disease. When your liver is damaged it can no longer remove toxic substances from your blood. These toxins build up and can travel through your body until they reach your brain, causing mental and physical symptoms of HE.

Explore this Hepatic Encephalopathy Information Center by clicking through to the Diagnosis, Treatment, Support and Caregivers landing pages where you’ll find more information to help you manage Hepatic Encephalopathy.


Learn if you or someone you love is at risk of getting HE, what triggers this complication and how it’s exhibited.


Being confronted with a diagnosis of HE can be overwhelming. And because HE is a complicated condition, a multidisciplinary approach is often required to manage it.


If you’re living with HE or caring for a loved one with HE you’ll likely need emotional, physical or financial support at certain points in your journey.

Caregiver and patient

Simply put, a caregiver is anyone who is responsible for the daily needs of another person. Caregivers can be a friend, spouse, life partner, parent, sibling or other family member.

  1. Hepatic Encephalopathy is a brain disorder that develops in some individuals with liver disease.
  2. Approximately 70% of individuals with cirrhosis may develop symptoms of Hepatic Encephalopathy.
  3. In some cases, Hepatic Encephalopathy is a short-term problem that can be corrected. It may also occur as part of a chronic problem from liver disease that gets worse over time.

Angie M.

Caregiver for Brother…
Faces of Liver Disease

Charles D.

Hepatic Encephalopathy


Hepatic Encephalopathy Hepatitis C End Stage Liver Disease
Faces of Liver Disease

Jason D.

Alcohol-related Cirrhosis
Silhouette Man

Jeremiah B.

Caregiver for Wife…
Silhouette Woman

Joyce O.

Caregiver for Mother…

Karen S.

Primary Biliary Cholangitis
Lynette K

Lynette K.

Hepatic Encephalopathy

Clinical trials are research studies that test how well new medical approaches work in people. Before an experimental treatment can be tested on human subjects in a clinical trial, it must have shown benefit in laboratory testing or animal research studies. The most promising treatments are then moved into clinical trials, with the goal of identifying new ways to safely and effectively prevent, screen for, diagnose, or treat a disease.

Speak with your doctor about the ongoing progress and results of these trials to get the most up-to-date information on new treatments. Participating in a clinical trial is a great way to contribute to curing, preventing and treating liver disease and its complications.

Start your search here to find clinical trials that need people like you.

Last Updated on April 21, 2022


Share this page