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Hepatic Encephalopathy Information Center

Hepatic Encephalopathy, sometimes referred to as portosystemic encephalopathy or PSE, is a condition that causes temporary worsening of brain function in people with advanced liver disease. When your liver is damaged it can no longer remove toxic substances from your blood. These toxins build up and can travel through your body until they reach your brain, causing mental and physical symptoms of HE.

Explore this Hepatic Encephalopathy Information Center by clicking through to the Diagnosis, Treatment, Support and Caregivers landing pages where you’ll find more information to help you manage Hepatic Encephalopathy.


Learn if you or someone you love is at risk of getting HE, what triggers this complication and how it’s exhibited.


Being confronted with a diagnosis of HE can be overwhelming. And because HE is a complicated condition, a multidisciplinary approach is often required to manage it.


If you’re living with HE or caring for a loved one with HE you’ll likely need emotional, physical or financial support at certain points in your journey.

Caregiver and patient

Simply put, a caregiver is anyone who is responsible for the daily needs of another person. Caregivers can be a friend, spouse, life partner, parent, sibling or other family member.


Angie M.

Caregiver for Brother… I am responding with my experience with HE as I was a caregiver for my brother, Javier
Faces of Liver Disease

Charles DiAngelo

Hepatic Encephalopathy


Hepatic Encephalopathy Hepatitis C End Stage Liver Disease
Faces of Liver Disease

Jason Dedmon

Alcohol-related Cirrhosis
Silhouette Man

Jeremiah B.

Caregiver for Wife… I did not know anything about HE until my wife was on her deathbed due to liver
Silhouette Woman

Joyce O.

Caregiver for Mother… I currently take care of my 77 year old mother who has had cirrhosis for over 10

Karen S.

Primary Biliary Cholangitis
Lynette K

Lynette K.

Hepatic Encephalopathy
Silhouette Woman

Samantha W.

Caregiver for Husband… My name is Samantha Wood and my husband, Steven, was diagnosed with Hep C 9 years ago

Stan I.

Hepatitis C


Hepatic Encephalopathy Congenital Hepatic Fibrosis

Tracey N.

Caregiver for Husband… As the caregiver for the 7 years 9 months my husband waited for his transplant, HE was

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