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Autoimmune Hepatitis

Autoimmune hepatitis is a disease in which the body’s own immune system attacks the liver and causes it to become inflamed. The disease is chronic, meaning it lasts many years. If untreated, it can lead to cirrhosis and liver failure.

There are two forms of this disease. Type 1, or classic, autoimmune hepatitis is the more common form. This is the form that mostly affects young women and is often associated with other autoimmune diseases. Type 2 autoimmune hepatitis is less common and generally affects girls between the ages of 2 and 14.

Healthy Liver

HEALTHY

Fibrosis

FIBROSIS

Cirrhosis

CIRRHOSIS

Cancerous Liver

CANCER

The Healthy Liver

A healthy liver has the amazing ability to grow back, or regenerate when damaged.

Fibrosis

When treated successfully at this stage, there’s a chance your liver can heal itself.

Liver Cancer

Cirrhosis and hepatitis B are leading risk factors for primary liver cancer.

Liver Failure

Liver failure is a life-threatening condition that demands urgent medical care.

There are many different types of liver disease. But no matter what type you have, the damage to your liver is likely to progress in a similar way.

Whether your liver is infected with a virus, injured by chemicals, or under attack from your own immune system, the basic danger is the same – that your liver will become so damaged that it can no longer work to keep you alive.

Cirrhosis, liver cancer, and liver failure are serious conditions that can threaten your life. Once you have reached these stages of liver disease, your treatment options may be very limited.

That’s why it’s important to catch liver disease early, in the inflammation and fibrosis stages. If you are treated successfully at these stages, your liver may have a chance to heal itself and recover.

Talk to your doctor about liver disease. Find out if you are at risk or if you should undergo any tests or vaccinations.


What causes autoimmune hepatitis?

Your immune system normally attacks bacteria, viruses and other invading organisms. It is not supposed to attack your own cells; if it does, the response is called autoimmunity. In autoimmune hepatitis, your immune system attacks your liver cells, causing long-term inflammation and liver damage. Scientists don’t know why the body attacks itself in this way, although heredity and prior infections may play a role.


What are the symptoms and complications of autoimmune hepatitis?

Often, the symptoms of autoimmune hepatitis are minor. When symptoms do occur, the most common are fatigue, abdominal discomfort, aching joints, itching, jaundice (yellowing of the skin and whites of the eyes), enlarged liver, nausea and spider angiomas (blood vessels) on the skin. Other symptoms may include dark urine, loss of appetite, pale stools and absence of menstruation. More severe complications can include ascites (fluid in the abdomen) and mental confusion. In 10%-20% of cases, autoimmune hepatitis may present with symptoms like an acute hepatitis.


How is autoimmune hepatitis diagnosed?

Autoimmune hepatitis often occurs suddenly. Initially, you may feel like you have a mild case of the flu. To confirm a diagnosis of autoimmune hepatitis, your doctor will use blood tests and a liver biopsy, in which a sample of liver tissue is removed with a needle for examination in a laboratory.


How is autoimmune hepatitis treated?

The goal of treatment is to stop the body’s attack on itself by suppressing the immune system. This is accomplished with a medicine called prednisone, a type of steroid. Often times, a second drug, azathioprine (Imuran) is also used. Treatment starts with a high dose of prednisone. When symptoms improve, the dosage is lowered and azathioprine may be added. In most cases, autoimmune hepatitis can be controlled but not cured. That is why most patients will need to stay on the medicine for years, and sometimes for life. Unfortunately, long-term use of steroid can cause serious side effects including diabetes, osteoporosis, high blood pressure, glaucoma, weight gain and decreased resistance to infection. Other medications may be needed to control these side effects.


Who is at risk for autoimmune hepatitis?

About 70 percent of people with autoimmune hepatitis are women, usually between the ages of 15 and 40. Many people with this disease also have other autoimmune diseases, including type 1 diabetes, thyroiditis (inflammation of the thyroid gland), ulcerative colitis (inflammation of the colon), vitiligo (patchy loss of skin pigmentation), or Sjogren’s syndrome (dry eyes and dry mouth).

  • Are my symptoms that I am experiencing (if you are) such as fatigue and lethargy due to AIH?
  • Which type of Autoimmune Hepatitis do I have? Type 1 or Type 2?
  • What is the status of my liver?
  • Do I have liver damage?
  • Will I need a liver transplant?
  • Is it possible for me to have AIH along with other autoimmune diseases?
  • Will blood tests be performed to check for autoantibodies?
  • Will a liver biopsy be needed?
  • What kind of medications might be possible to treat AIH?
  • Will I be tapered off (dose reduced) over time if I respond well to therapy?
  • Will there be routine imaging/screening to check for other kinds of liver diseases such as liver cancer?
  • Will I need a booster vaccine of for Hepatitis A and Hepatitis B?

Support Groups Near You

Visit the American Liver Foundation support group page here to find the closest support group to you.


Online Support Groups

Visit the American Liver Foundation online support group at Inspire…

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Program In this American Liver Foundation webinar Dr. Sujit J. Janardhan of Rush University discusses the basic information about clinical trials including phases, benefits and risks of clinical trials, questions you should ask your healthcare team before joining a clinical trial, and where to find clinical trials. Jess Schnur, PBC

Ask the Experts Webinar: Autoimmune Hepatitis and Primary Sclerosing Cholangitis

Program An American Liver Foundation webinar aired February 4th, 2019 featuring Dr. Marion Peters, Chief of Hepatology Research at UCSF GI Division, Dr. Kidist Yimam, Director of Autoimmune Liver Disease at California Pacific Medical Center, Dr. Christopher Bowlus, Division Chief, GI and Hepatology at UC Davis School of Medicine and

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