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Extra collagen stiffens around tissue like it is supposed to in a healthy liver but, inflammation continues and leads to more stiffening. This is how fibrosis develops.
When the liver detects something dangerous it works hard to eliminate and clear the substance from our body. This activates an immune response which requires some inflammation.
Bile ducts become blocked due to inflammation and scarring or fibrosis, accumulating in the liver, where it gradually damages liver cells and causes cirrhosis, or fibrosis of the liver.
MASH tends to develop in people who are overweight or obese, or have diabetes, high cholesterol or high triglycerides. However, some people have MASH even if they do not have any risk factors.
Note: MASH used to be called nonalcoholic steatohepaitits (NASH).
In 2005 I was diagnosed with autoimmune hepatitis and later with MASLD. Was also told that I didn’t qualify for a liver transplant.
Do you realize that your liver is depending on you? It’s true. Even though you can’t see it hidden away under your rib cage, if your liver could speak to you, it would say: “I’m working hard…"
Excess alcohol use (or alcohol use disorder) is one of the most common causes of liver disease and is responsible for almost half of the cases of liver-related death in the United States and worldwide.
