Siva Karthik Varanasi, PhD

Pilot Research Award
$50,000 over one year

University of Massachusetts Medical School

Role of Hepatocyte Bile acid synthesis in shaping autoreactive CD8+ T cells during autoimmune hepatitis

Autoimmune Hepatitis is a rare form of autoimmune liver disease that are becoming increasingly common and pose a significant health risk. Bile acids that are critical for liver health, are dysregulated during liver diseases. Our proposed studies aim to uncover how bile acid synthesis and its dysregulation during autoimmune hepatitis promotes inflammation and liver damage, paving the way for new therapeutic targets with significant implications for human health.