Xiaodong Ge, MD, Tiến sĩ

Giải thưởng nghiên cứu thí điểm
$ 50,000 trong hơn một năm

The Board of Trustees of the University of Illinois - University of Illinois Chicago

Role of SPP1 in the Pathogenesis of PSC

Understanding the mechanisms driving the onset and progression of primary sclerosing cholangitis is key to identifying novel biomarkers and therapeutic targets. In this project, we will establish a new role for secreted phosphoprotein-1 (SPP1) in biliary epithelial cells and determine how biliary epithelial cells develop a liver progenitor cell-like phenotype to promote liver repair. This improved understanding of the molecular pathogenesis of this disease may define new therapeutic targets and potentially alter the approach to patients with primary sclerosing cholangitis and other cholangiopathies.. Please let us know if you would like to submit an amended version for our website.